During the eighth over, Charles attempted a slog sweep off Kuldeep Yadav, but failed to connect it well.
Positioned at deep mid-wicket, Varma exhibited remarkable athleticism by sprinting at least 15 meters to his left, dived, and grabbed a stupendous catch.
WATCH:
Varma made his T20I debut alongside Mukesh Kumar on Thursday.
In addition to his remarkable fielding contributions, where he successfully took two catches (Charles and Nicholas Pooran), Varma showcased his batting prowess by smashing a brilliant 39 runs off just 22 balls, including three sixes and two fours.
India lost the match by 4 runs.
With this win, West Indies took 1-0 lead in the five-match series.
The second T20I will be played on Sunday at Providence Stadium in Guyana.